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Fundamental definition and core mechanisms of oxidative stress Oxidative stress refers to a pathological state in which the rate of ROS and reactive nitrogen species (RNS) production exceeds the scavenging capacity of endogenous antioxidant systems, leading to oxidative damage of biomolecules (e.g., DNA, proteins, lipids) 7,13

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Here, a luminescent-based assay was applied to CuCl-treated HepG2 and HepG2 ATP7B-KO cells, in which RLU are proportional to HO levels (Fig

A novel role for human sulfiredoxin in the reversal of glutathionylation

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