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Additionally, due to its participation in the CD38/CD203a/CD73 adenosinergic pathway, CD38 has been identified as an effective predictor of anti-PD-1 antibody-based checkpoint immunotherapy responses (49)

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Whether its inclusion provides meaningful advantage over formulations containing only tirzepatide and B12 remains uncertain

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Huemer M, Diodato D, Schwahn B, et al