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Mailleux, F., Beauloye, C., Balligand, J

Beyond skeletal muscle, AICAR-mediated AMPK activation has been implicated in improving insulin sensitivity [152], reducing hepatic lipid accumulation [153], and exerting cytoprotective effects under metabolic stress [154], further underscoring its importance as a molecular probe and potential metabolic modulator

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The primary outcomes assessed included the one-repetition maximum (1RM) strength, indicators of muscle hypertrophy (as measured by DXA, CT, and biopsy), and rates of MPS (utilizing deuterated water as a tracer)