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This precise enzymatic action releases the fully intact, active, reduced glutathione directly into the cytoplasm, exactly where the mitochondria and cellular machinery need it to neutralize oxidative stress

In plants, TRx is known to regulate several enzymes in this way, however GRx also couples the GSH redox potential to these changes in thiol/disulfide state [19]

Novelli A, Rosi E

Antioxidants (Basel, Switzerland) 10(9):1438

More in-depth research that clarifies the roles of these components of the GST-detoxification system are much needed, in order to produce compounds that have minimal side effects and high GST selectivity

The liver stores are a bit irrelevant to someone who has PA or a B12 absorption problem though because the mechanism that is used to release them relies on the same mechanism that is used to absorb most dietary B12 so accessing any stores is at best very inefficient