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Coenzyme Q10 protects retinal cells against oxidative stress in vitro and in vivo

doi: 10.1126/scitranslmed.aav4319 137 ThankamFGDilisioMFDietzNEAgrawalDK

Mechanistically, the CD73/A2AR signaling cascade coordinates the de novo synthesis and consumption of GSH with GSSG accumulation and concomitant mitochondrial lipid peroxidation, which links potentially to PKA/E2F1dependent fine-tuning of the ratio of GSR to GPX4

[DOI] [PMC free article] [PubMed] [Google Scholar] 25.Clark J., Clore E.L., Zheng K., Adame A., Masliah E., Simon D.K

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