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There is currently no antemortem diagnostic test available for PD (Tanner and Goldman 1996), making its diagnosis challenging

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595 Therefore, treatments that restore normal neurological function, or at least slow disease progression by targeting specific pathogenic mechanisms, remain warranted

Although the progression of neurologic complications is generally gradual, such symptoms may not be reversed with treatment of vitamin B 12 deficiency, especially if they have been present for a long time