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These ligands include the endogenous substrate Tf and several different antibodies and peptides that bind to different epitopes of the receptor with Tf as the most extensively studied ligand for TfR-directed brain targeting [20]

Peptide therapy isnt newits been used in medical research and clinical settings for decades

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Concerning the ApoE4 variant, regardless of AD diagnosis, older adults that are ApoE4 + display a greater level of A accumulation that is not evident in ApoE3 + or ApoE2 + individuals (Lim et al., 2017), and AD patients with the ApoE4 genotype ( +/+ or +/ ) display higher levels of intraneuronal A accumulation compared to controls, indicating a baseline detrimental cognitive effect (Yamazaki et al., 2019)

[DOI] [PubMed] [Google Scholar] 25.Hollander D., Kaunitz J.D