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An R-based Limma package available via Bioconductor 2.11 was used to generate quantitative methylation values ( -values) to identify regions of differential methylation

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Caffeine-induced A 1A R activation improves linked downstream signaling pathways, decreasing proinflammatory and enhancing anti-inflammatory responses, which reduce oligodendrocyte cytotoxicity and preserve the integrity of the myelin sheath and accompanying axon [63]