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However, the efficacy of immunotherapeutic agents is often hindered by the immunosuppressive tumor microenvironment, which impedes effective penetration and leads to rapid metabolism and short residence times at the tumor site, resulting in insufficient activation of immune responses and limited therapeutic outcomes

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10.1016/j.jep.2015.02.026 Summary Keywords therapeutic polysaccharides of natural origin, type 2 diabetes mellitus, structural characterization, complications of type 2 diabetes mellitus, mechanism Citation Liu Z, Wang H, Gong X, Jiang X, Yang K, Jiang L, Wang Z and Tong Q (2025) Recent advances in natural polysaccharides for type 2 diabetes management: sources, structural characteristics, and mechanistic insights
