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The patient-reported benefit is real but confounded

doi: 10.1016/j.freeradbiomed.2015.12.002

Glutathione conjugates are exported and excreted into the bile, provoking an irreversible loss of the cysteine residue of glutathione, a limiting step for its synthesis

However, the largest Phase IIb trial involving 536 participants failed to demonstrate statistically significant weight loss compared to placebo at the primary 12-week endpoint, leading to development termination in 2007

Prostate 68 , 517529 (2008)

For a full breakdown of exactly what raises creatinine, what doesn't, and a kidney-specific safety table, see our dedicated guide: Can Glutathione Increase Creatinine