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In addition, a TNF- surge or a cytokine storm ( aroA mutant has been shown to paradoxically induce higher TNF- production than its unattenuated counterparts (125)

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Phase I and Phase II detoxification pathways work together to process everything from environmental pollutants to metabolic byproducts

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Li X, Zhao Y, Gong S, Song T, Ge J, Li J, et al

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Clinical trial on edaravone demonstrated a significant reduction in the ALSFRSr score in ALS patients compared to placebo group [262,263]

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(PubMed) Pennington JAT, Schoen SA, Salmon GD, Young B, Johnson RD, Marts RW

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PubMed, Venn, Bernard J., et al

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