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The first study ex vivo in Ussing chambers (1999) evaluating the epithelial barrier function in colonic tissue from UC patients with mild or moderate macroscopic disease activity showed a 50% decrease of the total electrical wall resistance (assessed by transmural impedance analysis) when compared to healthy subjects

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P = 0.03) curative effect was recorded (Santoro et al., 2013)
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DNA methylation and Transcriptome Changes Associated with Cisplatin Resistance in Ovarian Cancer

[103] first showed effective lignan metabolic engineering
