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While Epithalon did not significantly influence food consumption, body weight, or mean life span, it did slow down the age-related switching-off of estrous function, decreased the frequency of chromosome aberrations in bone marrow cells, and significantly increased the maximum life span (by 12.3%) and the life span of the last 10% of survivors (by 13.3%)

DMSO or Palbociclib was also included in the extracellular solution for the experiments with pre-treatment

where, As is the absorbance of experimental wells (medium containing cells, CCK-8, sample to be tested)

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PMID: 46 HouSLiCWangYSunJGuoYNingXet al