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In regard to older adults without any cognitive impairment (objective or subjective), recent studies have reported that 22% to 24% of older adults without cognitive symptoms have Alzheimer's disease biomarkers

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De novo sequencing serves as a powerful complement: Identifying "Missing" Peptides: It can identify peptides that are not found by database searches, potentially due to sequence errors in the database, novel splice variants, or unannotated genes

Cryotherapy risks primarily involve direct cold injury (frostbite) from excessive exposure duration or temperature

GSH is a key intracellular thiol that helps neutralize ROS and maintain the balance between protein thiols and disulfides

doi: 10.1038/s41588-021-00887-y 23 PraharajMShenFLeeAJZhaoLNirschlTRTheodrosDet al
