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This paper was published in Neural Regeneration Research (Vol 9, No 10, 2014)

High doses should be taken under medical supervision, especially considering the potential risk of masking vitamin B12 deficiency symptoms[218]

However, a trial involving 22,845 AD patients showed that those treated with AChEIs had higher risks of appetite disorders, insomnia, or depression compared to those receiving a placebo ( Traditional Chinese medicine treats AD primarily by regulating gut microbiota balance to inhibit TMAO production

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