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Activates the VEGFR2-Akt-eNOS axis, modulates the NO system, promotes local angiogenesis Sequesters G-actin via the LKKTETQ motif, promotes cell migration and systemic angiogenesis 15 amino acids (pentadecapeptide), sequence GEPPPGKPADDAGLV, approx

Endothelial cells seeded on a three-dimensional matrix, such as Matrigel, are able to form capillary-like structure.34 HUVECs plated on Matrigel in limiting medium with increasing concentrations of BPC-157 formed more extensive tubes in a dose-dependent manner (Figure 5EF)

Microneedle treatment increased permeation to 4.4 ug/cm2/h

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