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Altered secretome The altered secretory phenotype in inflammatory cell senescence includes (1) altered nucleic acid secretion, such as micronucleus formation and disruption, leakage of mtDNA, release of LINE1, which may activate RIG-I-MAVS or cGASSTING signaling pathways to initiate an inflammatory response

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This disturbs the mitochondrial membrane potential and impacts motor proteins crucial for correct mitochondrial transport along axons and dendrites

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Cell 180 , 688702 (2020)

For active site identification, the CASTp server [9] was employed to define the taxane-binding pocket coordinates