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A further strategy is to design smart engineered bacteria capable of sensing disease states (such as specific metabolites or pH changes) and responsively releasing therapeutic proteins (such as anti-inflammatory cytokines and enzyme inhibitors)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 9.He X., Wang X., Fang J., Chang Y., Ning N., Guo H., Huang L., Huang X., Zhao Z