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Evading pre-existing anti-hinge antibody binding by hinge engineering

GAGs exhibit potent affinity for BAPPs via nonspecific or specific interactions

10.1001/archopht.1978.03910050179015 [DOI] [PubMed] [Google Scholar] Hrelec M., Klicek R., Brcic L., Brcic I., Cvjetko I., Seiwerth S., et al

The FDAs letters suggest that claims suggesting equivalence to approved drugswhether direct or impliedmay face enforcement action

Overall, Wells Fargo's efficiency strategy appears to be delivering gradual improvements in profitability and operating leverage

Science 292 , 872873 (2001)
