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This significantly increases the local concentration of the drug in the TME and significantly reduces off-target toxicity to normal tissues [91]

Bijalwan S

Disruption of the tight endothelial junction can be achieved via the use of a hyperosmotic agent to produce osmotic disruption or use of a vasoactive compound, bradykinin analogs, or other molecules [3]

Yet, a pertinent question, especially for individuals at risk for bone loss and muscle wasting, is whether IF protocols offer opportunities for meeting protein recommendations (Reference Tinsley and Paoli90)
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