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It is widely recognized that during DNA damage repair in germ cells, oocytes first induce mild DNA damage during the lengthy meiotic M phase and then repair the damage in the later stages of the cell cycle

Biochem Soc Trans 41:15881592 Scheiber IF, Mercer JF, Dringen R (2014) Metabolism and functions of copper in brain

Activation of AMPK/p38/Nrf2 is involved in resveratrol alleviating myocardial ischemia-reperfusion injury in diabetic rats as an endogenous antioxidant stress feedback
Ahmadi FA, Grammatopoulos TN, Poczobutt AM, Jones SM, Snell LD, Das M, et al

This stacking approach lacks formal study but has theoretical basis
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