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Although its etiology is still unclear, it has been established that environmental factors and susceptibility genes are involved in the pathogenesis of the disease

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Many candidates failed to demonstrate meaningful weight loss in the clinic due to potency, selectivity or side effect profiles, leading pharmaceutical companies to dismiss the use of melanocortin compounds for treating general obesity

[DOI] [PubMed] [Google Scholar] 236.Fabrizi F, Poordad FF, Martin P

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Mechanistically, TMAO exacerbates IBD pathogenesis by modulating key signaling pathwaysincluding endoplasmic reticulum stress (ERS) via protein kinase RNA-like endoplasmic reticulum kinase (PERK) activation, NF-B-driven proinflammatory cytokine production, and NLRP3 inflammasome-mediated pyroptosisthereby disrupting intestinal epithelial integrity, amplifying macrophage and T cell activation, and skewing immune homeostasis toward a proinflammatory milieu