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Kelch-like ECH-associated protein 1 (KEAP1) is a natural inhibitor of Nrf2 that negatively regulates its activity by proteasomal degradation (Singh et al

Within the H-site, the substrate analogue ( 12 ) interacts through hydrogen bonds to N108 and the backbone of V12, a interaction with F112, water bridges to R16 and Y175, and hydrophobic interactions with V12 and V115 (Fig

Thermal processing induces changes in the structure of allergenic proteins (193)

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When GSH is present, CBL is conjugated with GSH by the induction on the specific transferase hGSTA1-1 [34], thus inducing an efflux from the cells and reducing CBL activity