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Description
The extent of the reduction in enzyme activity depends on the specific combination of variations a person has

Another issue can be oven temperature

American journal of human genetics 62, 10441051, doi:10.1086/301825 (1998)
Brain Behav Immun 22: 11171127, 2008

Pesticide exposure and Parkinsons disease: epidemiological evidence of association

It has been reported that the mutations in GSR gene cause glutathione reductase deficiency leading to reduced lifespan of red blood cells (RBCs) 12
