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Effect of the onecarbon unit cycle on overall DNA methylation in children with Downs syndrome

Chen Z, Zhong C

10.1038/S41586-019-1034-5 [DOI] [PMC free article] [PubMed] [Google Scholar] Kobayashi EH, Suzuki T, Funayama R et al (2016) Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription

This epigenetic silencing effectively inhibits class-switch DNA recombination (CSR), somatic hypermutation (SHM), and plasma cell differentiation, thereby reducing the production of both T-dependent and T-independent autoantibodies (e.g., anti-dsDNA antibodies)

Edema may disappear overnight during sleep and becomes minimal in the morning at the time of rising from the bed due to the absence of effect of gravitational forces on blood vessels and lower limp

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