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184 The results showed that the mean pain scores on a NRS decreased from 7.5 at 1 month to 2.9 at 12 months, and the RDQ decreased from 12.6 at 1 month to 2.8 at 12 months

Hur 2015), and a growing body of laboratory, animal, and human research indicates metformin may normalize the disturbed microbial balance associated with abnormal glucose metabolism (Pryor 2015

J Biol Chem May 23;272(21): 13527-33 (1997)

Ischemia-reperfusion induces renal tubule pyroptosis via the CHOP-caspase-11 pathway
Additionally, its ability to reduce stress by stabilizing the hypothalamic-pituitary-adrenal (HPA) axis and lowering cortisol levels may further alleviate depressive symptoms (3)

Kosov, K., Klma, M., Pril, I