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But the roles of ferroptosis in other cardiovascular diseases, including valvular heart disease, have been rarely studied, which require further researches

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Additionally, the oxidative degradation of PUFAs generates two secondary lipid peroxides, 4-hydroxy-2-nonenal (4-HNE) and malondialdehyde (MDA), which are highly expressed during the onset of ferroptosis and serve as markers of this process