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Description
Chinnusamy et al., 2003)

Lancet Microbe 6, 101062
Length: 12'11

J., Schrader L

Adverse childhood experiences (ACEs) dysregulate HPA axis reactivity, increase baseline stress sensitivity, and prime the brains reward circuitry to respond more strongly to stimulant reinforcement

Among the various regulatory factors, peroxisome proliferator-activated receptor (PPAR) coactivator 1 (PCG-1), the master regulator of mitochondrial biogenesis, emerges as an important component involved in the defective mitochondrial biogenesis in CKD (Sharma et al., 2013
