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Increasing Dose: What the Evidence Shows A common misconception is that tolerance means the drug no longer works

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[DOI] [PMC free article] [PubMed] [Google Scholar] 286.Schwab K., Frahm S., Horsley D., Rickard J.E., Melis V., Goatman E.A., Magbagbeolu M., Douglas M., Leith M.G., Baddeley T.C., et al

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Each 10C increase roughly doubles reaction rates, which is why refrigeration (versus room temperature) dramatically extends shelf life

Evidence of mitochondrial dysfunction in fibromyalgia: deviating muscle energy metabolism detected using Microdialysis and magnetic resonance