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Psychiatry 69, 1118

Cai X, Deng L, Ma X, et al

In contrast to GH -/- mice, IGF-1 -/- mice show a proportional reduction in kidney weight when compared to wild-type mice

The frequency of injections can vary based on individual needs and healthcare provider recommendations, but they are often administered once or twice weekly

This phenomenon disrupts the balance between bone formation and resorption, thereby promoting the production of proinflammatory cytokines, which can interfere with the osteoprotegerin/receptor activator of NFB ligand balance, creating a pro-osteoclastogenesis environment favouring bone loss [48]

However, sustained high doses, overdose, fasting, alcohol use, or pre-existing liver disease can overwhelm glutathione reserves, increasing risk of hepatotoxicity and oxidative stress