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We identified only two cases of invasive melanoma in male patients in the fifth and sixth decade of life, demonstrating that this neoplasm is very rare in the mouth, particularly amelanotic melanoma.8 Immunohistochemistry for S100 and melan A was important for diagnostic confirmation and differential diagnosis

Dermoscopy, the examination of a lesion using a dermatoscope, can be helpful in the diagnosis of suspicious lesions

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