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Step 1: One week prior to sauna Obtain approval from your healthcare provider to sauna, and always consult your healthcare team before adding any dietary supplements to your regimen

Statistical analysis All data are presented as means standard error of the mean (SEM)

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Parallel reaction monitoring (PRM) transitions assessed are within the 300-1,800 scan range

Buccal mucosae were evaluated for keratin thickness, area % of iron deposition, area% of immunoreactivity to nuclear factor erythroid 2-related factor 2 (Nrf2) and glutathione (GSH) tissue level using one-way ANOVA and post hoc tests