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The combined actions of these activated microglia-derived factors can lead to cellular damage and dysfunction, exacerbating the neurodegenerative processes associated with various neurological disorders [359,360]
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Environmental Protection Agency,, Washington, DC Frei E, Kuchenmeister F, Gliniorz R et al (2001) N-nitrososdimethylamine is activated in microsomes from hepatocytes to reactive metabolites which damage DNA of non-parenchymal cells in rat liver