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As shown inTable 1, evidence that early exposure toAPAP causes neurodevelopmental injury in susceptible babies and children is much more robust than that limited to prenatal exposure only (Table 1)

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Archier E, Devaux S, Castela E, Gallini A, Aubin F, Le Maitre M,

PMID 1362956

In EAE mice, adoptive transfer of itaconate-treated, Th17-polarized T cells significantly ameliorated disease severity (173), highlighting the potential of targeting metabolic pathways to modulate the Th17/Treg balance in autoimmune neuroinflammation

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