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The aqueous solubility of glutathione allows it to function effectively within the cytoplasm of cells, where it plays a critical role in detoxification processes

2021 Mar 30;22(7)

Most recently, researchers in Pomona, California, found significant improvements in cognitive function in a mouse model of Angelman Syndrome, a genetic disorder which, amongst other abnormalities, presents as severe deficits in both motor and cognitive functions

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Figure 2 4.1 Key molecular pathways related to neuroinflammation-mediated ferroptosis 4.1.1 Cyclic GMP-AMP synthase/stimulator of interferon genes The stimulator of interferon genes (STING) pathway is activated by double-stranded DNA (dsDNA), which activates the expression of interferon (IFN) via interferon regulatory factor 3 (IRF3) (Liu et al., 2015)

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