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In Cycle 1, CRS occurred in 5% of patients after the 0.16 mg dose (Cycle 1, day 1), 3.8% after the 0.8 mg dose (Cycle 1, day 8), 2.3% after the 3 mg dose (Cycle 1, day 15), and 18% after the first 48 mg dose (Cycle 1, day 22)

10.3109/07420528.2011.618896 Summary Keywords sleep deprivation, DNA methylation, histone modifications, microRNAs, long non-coding RNA Citation Gaine ME, Chatterjee S and Abel T (2018) Sleep Deprivation and the Epigenome