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Individuals at higher risk include older adults with reduced stomach acid production, people with gastrointestinal conditions affecting absorption, strict vegans, and those taking medications like metformin or proton pump inhibitors

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The metabolic changes come from cellular-level effects rather than artificially elevated sympathetic tone

The compound exhibits the molecular formula C165H269N47O46 with a molecular weight of 3647.15 g/mol and consists of 29 amino acids representing a modified version of the first 29 amino acids of endogenous GHRH