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In addition to these properties, ET can chelate divalent cations such as Cu 2+ , Zn 2+ , Ni 2+ , and Zn 2+ , and chelation of Cu 2+ accounts for its ability to counteract Cu 2+ -mediated DNA damage (45, 91, 138)

MOTS-c: a promising mitochondrial-derived peptide for therapeutic exploitation

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This FDA-approved peptide therapy has the unique ability to target areas of the body where there are abnormally high levels of fat, and works wonders when combined with exercising and consuming a lower calorie diet

Contributor Information Rotem Ben-Shachar, Email: [email protected]

In the PRO2TECT study 130 , the oral HIFPHD inhibitor vadadustat was non-inferior to darbepoetin alfa with regards to haematological efficacy but did not meet the prespecified non-inferiority criterion for cardiovascular safety in patients with non-dialysis-dependent chronic kidney disease