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While the exact mechanisms remain unclear, two primary theories have been proposed: 1) an immune-mediated systemic reaction causing vasoconstriction and a prothrombotic state leading to ischemia and subsequent stroke

The ATM specific kinase inhibitor KU60019 (Tocris, UK) was dissolved in DMSO to 100 mM then diluted to 5 M directly into media
Goulas, A., Betzel, R

Apart from this, gut microbiota play a decisive role in maintaining the homeostasis and health of the host via direct involvement in gut structure and morphology, regulation of immune responses, and protection from luminal pathogens

It is important to note, however, that patients in the duloxetine group reported more moderate-intensity adverse effects (fatigue, somnolence, insomnia) compared to those in the placebo group, which resulted in a higher dropout rate (11% vs
