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[16] Reduction in leptin levels are linked to greater food satiety

A 2025 matched-cohort study found men who started testosterone therapy had significantly higher rates of tendon tears and repairs at one and two years compared to controls, a pattern the authors attributed to testosterone's effect on tendon biomechanics outpacing the tissue's regenerative capacity Sherman et al

While these immediate effects can be encouraging, they are often short-lived unless supported by regular injections and other complementary treatments or lifestyle changes

Pharmacology (2015) 95(1-2):95103

Neither form should be used casually

Weeks 5-6: Continued improvement for most conditions