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Like Jerne, Burnet had long questioned the instructionist theories and in 1948 published a paper with his colleague Frank Fenner in which they attributed antibody production to 'the existence and modification of self-replicating units within the antibody-producing cells' Importantly by the late 1940s Burnet had begun to contemplate antibody formation from the cellular perspective (Burnet, Fenner

However, to the best of our knowledge, the role of environmental alkalinization in the pathogenesis of A
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