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In pre-symptomatic PD patients (e.g., those with RBD), this dysbiosis reduces short-chain fatty acid-producing bacteria, further elevating permeability and facilitating CNS infiltration of inflammatory mediators like LPS and -Syn (73)

Recently, a phase-2 trial called BeatMG, designed to test the efficacy of RTX treatment in AChR patients with mild to severe disease, ended (ClinicalTrials.gov Identifier: NCT02110706), while a phase-3 trial called RINOMAX is currently in progress with patients that have moderate to severe disease (ClinicalTrials.gov Identifier: NCT02950155)

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NAD+ is well-tolerated and rarely interacts with medications, but a full review of your health history is essential