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Author contributions XM: Methodology, Formal Analysis, Software, Writingoriginal draft, Funding acquisition

After HT22 cytotoxicity evaluation compound 36 was found to have low cytotoxicity (CC 50 = 18.8 M) and its inhibitory activity was 16 times higher than that of OLZ (EC 50 = 0.074 M)

Nofreezing reconstituted peptides causes ice crystal formation that physically disrupts peptide structure and reduces bioactivity by 4060%

Time-course evaluation of brain regional mitochondrial bioenergetics in a pre-clinical model of severe penetrating traumatic brain injury

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