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The majority of other retroviral proteases also have one or more cysteine and/or methionine residues at the dimer interface region and modification of these residues, under conditions of oxidative stress, would be predicted to similarly regulate dimerization and activity 8

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Although many of these innovative treatments are designed to mitigate side effects, ROS-based therapies can still cause unintended oxidative injury to normal tissues [303]

D.NusinowitzS.et al (2000)

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We previously investigated spatial lipid alterations within coronal brain sections taken at 6 mm relative to the ac in the same individual animals, focusing on basal ganglia regions, including the GPi, GPe and substantia nigra reticulata (SNR), and reported specific distributions and alterations in hydroxylated and non-hydroxylated sulfatides in control and MPTP primates 42