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More damaged tissue = longer therapeutic activity Mild inflammation = shorter duration of action This is why users healing from surgery or major soft tissue injuries may feel benefits weeks after their last dose

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In surgery, salvage methods include the reattachment of various muscles, i.e., quadriceps [1,2], masticatory muscles [3], lateral pterygoid muscle [4,5,6], mentalis muscle [7], and temporalis muscle [8], as well as other procedures [9,10]