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XRPD, X-ray powder diffraction

Although, clinical efficacy of TYK2 inhibitor, deucravacitinib, for psoriatic arthritis (PsA) has been reported [ A 46-year-old Japanese woman with a 25-year history of plaque psoriasis had been treated with 8 mg weekly of methotrexate for the last 2 years for concomitant PsA on the right wrist, fingers, and knee, which developed 3 years before

A candidate for a potential glutathione-scaffold residue was identified using the following selection criteria: The residue should be rather conserved in enzymatically active in contrast to inactive glutaredoxins and have a charged side chain to ensure a strong ionic glutathione interaction (Fig

However, to date, oligonucleotide therapeutics are still facing some technological obstacles, such as how to achieve efficient oligonucleotide delivery to target organs or tissues, how to overcome off-target interactions [4952], and how to address the sequence- and chemistry-dependent toxicity and saturation of endogenous RNA processing pathways [53, 54]