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Sorafenib has been shown to induce ferroptosis in HCC models by inhibiting the cystine/glutamate antiporter system Xc - and affecting key antioxidant enzymes (69, 70)

Revisiting the effects of different dietary sources of selenium on the health and performance of dairy animals: a review

PFK15, a first-in-class small molecule antagonist of PFKFB3, blocks cell cycle proteins to induce G0/G1 arrest and induces mitochondrial apoptosis

In models of lung and breast cancer, targeting Apelin prevented resistance associated with anti-angiogenic therapy by reducing tumor growth, metastasis and improving vessel function [188]

Surgery: Surgery can be used to treat nerve pain, but it is not common with BPI

[DOI] [PubMed] [Google Scholar] 10.Zhou X.J., Vaziri N.D., Wang X.Q., Silva F.G., Laszik Z