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These include altered choline metabolism, changes in neurotransmitter metabolism, defective DNA methylation with consequent poly (ADP-ribose) polymerase (PARP) overactivation and PARP-controlled cell death, excitotoxicity, up-regulation of re-entry to the cell division cycle, hypomethylation of myelin lipids and myelin basic protein, white matter changes, and the formation of homocysteine thiolactone and subsequent protein homocysteinylation (89)

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doi:10.1016/S0092-8674(00)81441-5
