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A 2018 meta-analysis in Psychosomatic Medicine found that acetyl L-carnitine supplementation had significant antidepressant effects, particularly in older adults (Veronese et al., 2018)
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In contrast, in obese human subjects under fasting conditions, the increase in urinary excretion of acetylcarnitine was markedly slower and at a lower level, suggesting a slower formation of acetyl-CoA derived from fat oxidation
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