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Benke, D., Honer, M., Michel, C

The most-affected pathways include antioxidant defense, DNA repair, ubiquitin-proteasome activity, and TGF-beta signaling

Genes were clustered hierarchically based on the average topological overlap measure, and modules of coexpressed genes were identified using the cutreeDynamic function with the parameters minClusterSize set to 30, deepSplit set to three and pamStage set to false

Dosages are patient-specific but generally fall within a well-established therapeutic window

Using a clean and stable environment for administration